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Although until time very recently the benefit of the hormone replacement therapy was accepted to prevent the coronary heart disease in postmenopausal women, now there are recommendations against it, these are born from the first controlled clinical trial that is devoted to the topic. A possible explanation to the contradiction between the observational studies that supported the employment and the clinical trial that doesn't find the benefits, can be the inherent biases to the first ones. It is carried out a revision of some of the biases that have already been demonstrated.

Terapia de reemplazo hormonal y enfermedad coronaria: beneficios explicados por los sesgos en la investigación