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Objective:  To estimate the association between genetic markers D19S884 and UCSNP-19 and Polycystic Ovary Syndrome (PCOS). Materials and methods:  Study of 50 cases of PCOS consistent with the Rotterdam criteria and of 100 controls and two first-degree female relatives without the disease. Social, demographic and clinical characteristics were assessed, and genetic markers D19S884 and UCSNP-19 were identified using polymerase chain reaction. Quantitative variables are expressed as mean ± standard deviation; the Student t test and the McNemar test were used. Odds ratios and 95% confidence intervals were estimated. Results:  Mean ages were 23 ± 6 years and 39 ± 18 years for the cases and controls, respectively. Cases showed a significant association with hirsutism OR = 3.6 (CI 95%: 1.3-12.8) and acne OR = 4.3 (CI 95%: 91.4-17.4). Del/ins and ins/ins polymorphisms of UCSNP-19 were found in the highest proportions in the two study groups, the former being more frequent among the cases and the latter among the controls. However, this difference was not statistically significant. Fourteen alleles of D19S884 were identified, ranging from 215 to 242 bp. Conclusions:  No association was found between the CAPN10 gene UCSNP-19 polymorphism and the D19S994 marker with PCOS in the population studied.

revista colombiana de obstetricia y ginecología/revista colombiana de obstetricia y ginecología

Marcadores genéticos en pacientes con síndrome de ovario poliquístico y dos de sus familiares en primer grado de consanguinidad. Estudio de casos y controles