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Objective:To assess diagnostic concordance between placental alpha macroglobulin-1 (PAMGDOI 1) and insulin-like growth factor-binding protein 1 (IGFBP-1) tests in patients with uncertain diagnosis of rupture of membranes.Materials and methods: Diagnostic concordance cross-sectional study in pregnant women with clinical suspicion of rupture of membranes seen at Hospital Universitario San Vicente Fundacion de Medellin (HUSVF) between August 2014 and December 2015, in whom two diagnostic tests for the diagnosis of rupture of membranes were compared. Patients in advanced labour were excluded. Concordance of test results was estimated in terms of the presence or not of ruptured membranes, using the Kappa Index.Results: Of 83 patients, 27.7 % were positive for rupture of membranes when the PAMG-1 (Amnisure) was used and 28.9 % were positive with the IGFBP-1 (Actim-Prom) test; the only case of disparity was positive to amniotic infusion of indigocarmine. Concordance between both tests was 0.97.Conclusion: The performance of IGFBP-1 was similar to that of PAMG-1 for diagnosing rupture of membranes.

revista colombiana de obstetricia y ginecología/revista colombiana de obstetricia y ginecología

Estudio de concordancia entre dos pruebas: alfa microglobulina placentaria tipo 1 (pamg-1) frente a factor de crecimiento similar a la insulina tipo 1 (igfbp-1), en pacientes con diagnóstico incierto de ruptura de membranas, Medellín, Colombia