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A simple, economic, precise, sensitive and accurate HPTLC/densitometry method of analysis for determination of vilazodone HCl in both bulk drug and in tablet formulation was developed and validated. The method employed TLC aluminum plates precoated with silica gel 60 F 254 S as the stationary phase. The solvent system consists of toluene:chloroform:methanol (2:2:1). This system was found to give compact spots for vilazodone HCl (R f value=0.45). Densitometric analysis of vilazodone HCl was carried out in the absorbance mode at 242 nm. The linear regression analysis data for the calibration plots showed good linear relationship with r 2 =0.997 with respect to peak height and peak area, in the concentration range of 200-1200 ng/band. The method was validated as per the ICH guidelines for various parameters like recovery, precision, repeatability and reproducibility. The results obtained proved that the method can be employed for routine analysis of Vilazodone HCl in bulk as well as in tablet formulation. The proposed method also indicates no interference of excipients from tablet formulation.

Development and Validation of HPTLC/Densitometry Method for the Estimation of Vilazodone HCl in Bulk and in Tablet Formulation