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Two rapid, specific and economic methods have been developed using methanol as solvent for spectrophotometric determination of vilazodone HCl in bulk and in tablet formulation. Vilazodone HCl showed maximum absorption at 241nm (method A) and same spectrum was derivatised into first order derivative at Ae=2; amplitude of trough was recorded at 246nm (method B). In both methods vilazodone HCl follows linearity in concentration range 1-6μg/ml and exhibited good correlation coefficient (r 2 =0.999) and excellent mean recovery (98.32%) and (99.53%). The methods were validated statistically and by recovery studies for linearity, precision, repeatability, and reproducibility. The obtained results proved that both the methods can be employed for routine analysis of vilazodone HCl in bulks as well as in the commercial tablet formulation.

Development and Validation of Spectroscopic Methods for the Estimation of Vilazodone in Bulk and in Tablet Formulation