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Analytical results play a vital role in quality control of bulk drugs and pharmaceutical formulations. The main aim of this proposed research work is to study uncertainty estimation for quantitative determination of Galantamine hydrobromide from pharmaceutical formulation using ultraviolet spectrophotometry. The estimation of uncertainty was performed using cause effect (Ishikawa) diagram. Determination of uncertainty components proved to be a good way for experimental model to obtain low contribution of uncertainty to analytical results. This research paper explains identification of uncertainty sources, starting from a clear declaration of measured species, quantification of these uncertainty sources and a combination of these individual sources to estimate standard and expanded uncertainty. Determination of various components of uncertainty is a best method to confirm that results obtained of analytical methods are certain. It is concluded from the present study that uncertainty estimation for assay of Galantamine hydrobromide from pharmaceutical formulation is influenced by sample concentration rather than volumetric flask and sample mass. Thus sample concentration is the major factor to achieve precise results of the analysis.

Estimation of Uncertainty for Measuring Galantamine Hydrobromide in Pharmaceutical Formulation Using Ultraviolet Spectrophotometry