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The paper presents the results of clinical studies of safety, antigenic activity and effectiveness of the new vaccine «Verres-Coliclost» against escherichiosis and clostridiosis of pigs in conditions of pig-breeding enterprises of the Russian Federation. During the research it was established that the vaccine intended for immunization of pregnant sows is safe for single and double application at the recommended dose. When applying in a dose twice as high as recommended, deviations from the physiological norm in experimental animals were also not recorded. In the study of antigenic activity, a significant increase in antibody titer in experimental animals after double application of vaccine to E. coli K99, K88 and F41 antigens, as well as antitoxic antibodies to Clostridium perfringens type C and Clostridium novyi type B toxins has been established, which indicates a high antigenic activity of vaccine. Based on the results obtained in industrial conditions, vaccine can be recommended for the prevention of escherichiosis, anaerobic enterotoxemia and necrotic hepatitis of pigs.

russian journal of agricultural and socio-economic sciences

THE RESULTS OF CLINICAL STUDIES OF SAFETY, ANTIGENIC ACTIVITY AND EFFECTIVENESS OF INACTIVATED VACCINE «VERRES-KOLIKLOST» AGAINST ESCHERICHIOSIS AND CLOSTRIDIOSIS OF PIGS