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Around the world, cases of methanol intoxication are still common, especially in countries that prohibit the sale of alcohol freely. The mortality rate due to methanol intoxication is very high. Quick and precise diagnosis is still a challenge because special laboratory tests are needed to detect the presence of methanol in the blood. General practitioners often rely solely on clinical diagnosis and simple laboratory examinations to help diagnose methanol intoxication. This study aims to determine correlation between clinical diagnosis with qualitative levels of serum Methanol and correlation between indirect laboratory examination (pH, anion gap, lactate and blood osmolality) with quantitative levels of serum methanol in methanol intoxication patients. The research design used was analytic observational with cross sectional approach. The study subjects were patients with a suspected diagnosis of methanol intoxication in Dr. Saiful Anwar, Malang, East Java during the period of July 2016 until July 2018. The location of the study was at RSU Dr. Saiful Anwar, Malang, East Java; and forensic laboratories of East Java Regional Police, Surabaya. Data was recorded in a special registry which was then carried out by the Spearman correlation test to test the correlation between indirect laboratory results (pH, anion gap, lactate and osmolality) with quantitative levels of Methanol. The Fisher Exact test and Chi square test were used to examine the relationship between clinical diagnosis and qualitative test of serum methanol. The analysis program used is SPSS 20. Total 32 cases suspected of methanol intoxication, 3 cases in the exclusion criteria. Out of 29 cases, it was more common in men (83%) than women with mean age of 28.75 years. Fisher's Exact test results in p = 0.692 or greater than α = 0.05, so it was stated that there was no significant difference between clinical diagnosis and qualitative levels of serum methanol. From diagnostic tests, clinical diagnosis has a sensitivity value of 86.4% and a positive predictive value of 76% but its specificity value is only 14.3% and negative predictive value is only 25%. Spearman correlation test showed that there was a significant relationship between serum methanol levels with pH (p = <0.01), lactate (p = 0.012), anion gap (p = <0.01) and osmolality (p = 0.012). There was no significant relationship between clinical diagnosis and qualitative levels of serum methanol. There is a significant relationship between pH, lactate, anion gap and serum osmolality with quantitative levels of methanol.

biotika

Correlation between clinical diagnoses with qualitative levels of serum methanol and correlation between indirect laboratory examination with quantitative levels of serum methanol in methanol intoxication patients