English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

1,4 Senior Resident, Department of Endocrinology, Medical College, Kolkata 2 Associate Professor and Head, Department of Endocrinology, Medical College, Kolkata 3 Assistant Professor, Department of Endocrinology, Medical College, Kolkata Corresponding Author Dr Animesh Maiti Abstract Introduction: Type 1 diabetes is a disorder of chronic autoimmune destruction of pancreatic beta cells. Current model of type 1 diabetes shows that varying proportion of functioning beta cells persist even after symptomatic disease onset. This residual beta cell function can be assessed by measurement of fasting and stimulated C-peptide level. This residual proportion of beta cell mass could be associated with improved metabolic outcome. Objectives: Measurement of fasting and post OGTT (oral glucose tolerance test) C-peptide level in type 1 diabetes population and it’s correlation with duration of diabetes and antibody status. Methods: Observational, cross-sectional study carried out in the department of Endocrinology and metabolism, Medical College, Kolkata from march 2017 to January 2019.Total number of study subjects were 100 consecutive type 1 diabetes patients of 10 – 30 years of age. Results: Diagnosis of diabetes in majority of cases done by 12-18 years of age. Male to female ratio was 0.78: 1. Fasting C-peptide was detectable in 75 % of cases and after stimulation detectable Cpeptide increased to 89 %. Stimulated C-peptide values were significantly negatively correlated with duration of diabetes [rho= (-0.260) ; p=0.03]. Antibody positivity were found in 77 % of cases and out of that majority (47 %) cases were GAD-65 positive. Fasting and stimulated C-peptide values are significantly higher in antibody negative groups that antibody positive groups (p=< 0.001). Lowest mean fasting and stimulated C-peptide level were found in GAD-65 antibody positive groups. We found a significant negative correlation of stimulated C-peptide level with GAD-65 antibody titre in antibody positive groups (p=0.017). Conclusion: It can be concluded that progressive decline in C-peptide level was observed with increasing duration of diabetes. Antibody negative groups had higher residual beta cell mass than antibody positive groups.

journal of medical science and clinical research

A Study of Residual C-Peptide Level (Fasting and Post OGTT) in Type –1 Diabetes Population &amp; It’s Correlation with duration of Diabetes and Antibody Status in a Tertiary Care Centre in Eastern India