English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective: The objective was to investigate the expression of HPV16 L1 capsid protein in cervical neoplasia to analyse its association with different grades of cervical lesions and its implication as a prognostic marker. Materials and Methods: Detection of L1 capsid protein of HPV16 by immunostaining was done using anti-HPV16 mouse monoclonal antibody against L1 fusion protein in cervical scraping or biopsy specimens obtained from subjects (n=79) after confirmation of cytological/histological diagnosis. Results: Total 79 cases of cervical cancerous lesions in a graded spectrum were observed for expression of L1 capsid protein of HPV16, among which 30 cases showed L1 expression and 49 cases did not. The expression rates of L1 protein among ASCUS, ASC-H, LSIL and HSIL were 37.50%, 66.67%, 80% and 44.44% respectively. Among invasive lesions, the L1 expression rates were 25%, 15.38% and 8.33% in well, moderately and poorly differentiated SCC respectively. Overall the L1 positivity rate was 37.97%. The expression of L1 proteins decreased with increase in lesion grade. This declining trend of L1 positivity rate with increasing grade of lesion was extremely significant (p value for chi squared for trend is 0.0005). The difference of L1 expression between preinvasive and invasive group was also significant (p<0.0001). Conclusion: Expression of L1 capsid protein of HPV16 was high in lower grade preinvasive lesions and it steadily declined with increasing grade of lesion. HPV16 L1 Protein expression can be used as a prognostic tool and a marker of immune response against HPV16.

Expression of Major Capsid Protein L1 of Human Papilloma Virus Type-16 in Cervical Neoplasia and Its Implications