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Gynecologic tumors in children are rare and represent <5% of all pediatrics neoplasms (1) . Rhabdomyosarcoma (RMS) are malignant mesenchymal tumors originating from myogenic progenitor cells. They represent the most common soft tissue tumor in childhood. The head and neck region are the most affected tumor sites, followed by the genitourinary tract (2) . Four major histologic subtypes of RMS are identified, Embryonal, Alveolar, Botryoid, Pleomorphic/ undifferentiated (2,3) . Botryoid variant is a type of embryonal RMS arising within the wall of the bladder or vagina, can also occur in the cervix. This tumor is seen almost exclusively in infants, it is characterized by ‘grape-like’ appearance caused by polypoid mass arising in submucosal tissue (2,4) . Embryonal RMS of the vagina is a variant which represent an extreme rare and aggressive form associated with poor prognosis (2)

Rhabdomyosarcoma of the vagina in a 30-month-old girl: Refractory to conventional chemotherapy