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Background: The present study is to compare the efficacy of dexmedetomidine versus Lignocaine to attenuate hemodynamic response occurring due to laryngoscopy and endotracheal intubation in elective general surgery. Methods: A total of 60 patients aged 18-60 years, American Society of Anesthesiologists physical status I or II, either sex, scheduled for elective surgical procedures were included in this study. Patients were randomly using a computer generated random number table to two equal groups of 30 each, comprising of group dexmedetomidine (group D) 1 μg/kg diluted with 0.9% saline to 10 ml I.V. over 10min and group (L) 1.5 mg/Kg of Lignocaine diluted with 0.9% saline 10 ml I.V. given just before induction. Heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure were recorded at baseline, after 3 min of infusion, after induction and at 1, 3, 5 and 10 min after endotracheal intubation. Results: In group D, there was no statistically significant increase in HR and blood pressure after intubation at any time intervals, where as in group L, there was a statistically significant increase in blood pressure and heart rate after intubation at 1, 3, 5 and 10 min. Conclusions: Dexmedetomidine 1 μg/kg is more effective in attenuating the hemodynamic response to laryngoscopy and intubation than Lignocaine 1.5 mg/Kg in elective surgical patients.

Comparison of Efficacy of Dexmedetomidine versus Lignocaine in Attenuation of hemodynamic response to laryngoscopy and intubation