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Coronary Artery Disease (CAD) is a leading cause of death in men and women at a global scale. This condition has been increasingly threatening in young individuals in the recent years. In the current study we attempt to find the association of CAD with various cardiovascular risk factors among young individuals in a regional Eastern Indian population. Materials and Methods: CAD status of 55 subjects, determined by Histopathological (HP) analysis, following autopsy, was correlated with risk factors they were exposed in like history of smoking, alcohol consumption, physical activity level, stress level and socioeconomic status. Data were analysed using SPSS version 23.0, Armonk, NY, IBM Corp. Chi-square test with Yates correction and Fisher exact test were applied in univariate analysis. Binary logistic regression was applied to perform multivariate analysis of factors contributing to the CAD status. Results: Univariate analysis showed that smokers and alcoholics were significantly associated with higher grade of CAD (p < .05). Higher HP grade of CAD was significantly more commonly found among those who belonged to lower middle and below class of socio-economic status (p = .02). Also, sedentary physical activity status was significantly associated with higher level of HP grade of CAD (.000). However Binary logistic regression also showed that smoking, alcohol consumption and lower middle and below socio-economic status had significantly higher risk of developing higher HP grade of CAD while moderate physical activity status had a protective effect on development of higher HP grade. Conclusion: There is a high incidence of CAD in the young individuals and has been significantly associated with lower socioeconomic status, history of smoking and alcohol consumption and sedentary lifestyle. Moderate physical activity however has a protective effect from the condition.

journal of medical science and clinical research

Association between multiple cardiovascular risk factors and coronary artery disease in young individuals belonging to an Eastern Indian Population: A histopathology and autopsy-based study