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Background: Prostatic enlargement can present with various urinary tract symptoms due to its location at the bladder neck. Benign prostatic hyperplasia (B.P.H), prostatitis, Prostatic intraepithelial neoplasia (PIN) and adenocarcinoma are the lesions commonly encountered. Use of Prostate Specific antigen (PSA) levels as a screening test aids in the diagnosis and management of prostate cancer. Materials and Methods: This study was carried out for a period of 2 years in the department of pathology. A total of 160 cases of prostate biopsies were studied and PSA values were noted in 112 cases. The biopsies were processed by routine techniques and studied along with immunohistochemical (IHC) markers in cases of diagnostic problems. Results: The 112 cases of prostate biopsies which had PSA estimations have been analyzed here. The most common condition was B.P.H, found in 51%, Prostatitis in 15%, PIN in 9.2% and adenocarcinoma in 24%. Majority of the patients were in the age group of 60-69 years. PSA values in the benign cases were in the range of 4-10ng/ml, while malignant cases had levels >20ng/ml. Mean PSA values associated with benign lesions were 8.93, while in malignant cases they were 43.66. Conclusion: Incidence of adenocarcinoma of prostate is on the rise and therefore it is suggested to include PSA estimation as a screening test in males above the age of 50years.

Comparative Analysis of Serum Prostate Specific Antigen Levels in Various Prostatic Lesions