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Anal fissure is a common condition affecting all age groups, but it is seen particularly in young and otherwise healthy adults, with equal incidence across the genders. Glyceryl Tri Nitrate(GTN) is an NO donor which causes relaxation of internal anal sphincter and increases blood flow to allow the fissure to heal. Lateral internal anal sphincterotomy is the most common treatment for chronic anal fissure and can be effective.

A Comparative Study of Topical Glyceryl Trinitrate (0.2%) and Lateral Anal Sphincterotomy in Treatment of Fissure in Ano