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Background: Urticaria is a disease with weals and itching seen in all age groups. It can be acute or chronic, and chronic can be further subdivided into chronic inducible urticaria and chronic spontaneous urticaria. Till date some many antibodies have been found to be associated with chronic spontaneous urticaria. Autologous serum sensitivity test has emerged as one of the invasive investigations being tried in detecting the autoimmune nature of the disease. Through this study, we are trying to find out the association of antithyroid peroxidase antibody (anti TPO) with CSU (chronic spontaneous urticaria) and correlate the severity of CSU with ASST positivity. Objectives: To find out if there is any association of chronic autoimmune urticaria with anti TPO and ASST to correlate its severity with them. Method: Ours was a crossectional study whereby we have investigated all the enrolled patients for anti TPO and performed ASST on them. A total of 137 consecutive patients were enrolled and investigated for serum anti TPO and ASST performed on them. The datas were analysed using SPSS software 2019 version. Result: In this study anti TPO antibodies and ASST was found to be positive in patients of CSU .While anti TPO has come out to be a screening tool and ASST a better diagnostic tool. Conclusion: We can conclude from the study that CSU is associated with anti TPO.

To study the association of chronic spontaneous urticaria with anti thyroid peroxidase antibody and ASST