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1,2,6 Department of Geriatrics and Gerontology, Faculty of Medicine –Ain Shams University. Cairo, Egypt 3,5 Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine – Ain Shams University, Cairo, Egypt 4 Department of Orthopedic Surgery, Faculty of Medicine – Ain Shams University, Cairo, Egypt *Corresponding Author Maram Maher Monier Department of Geriatrics and Gerontology, Faculty of Medicine – Ain Shams University, Cairo, Egypt Abstract Background: Osteoarthritis (OA) is the most prevalent etiology for arthritis. Knee OA clinical symptoms and signs have direct impact on social interactions, mental functioning, sleep quality and various aspects of patients’ lives. The applications of biologic managing agents such as PRP in musculoskeletal disorders are growing considerably. Aim: To investigate and compare gender differences in response to platelets rich plasma intra articular injections in cases having knee osteoarthritis. Methodology: The research clinical trial recruited 44 elderly participants aged sixty years and above with mild to moderate knee osteoarthritis according to Kellgren-Lawrence Grading Scale system. The studied sample have been categorized into two equal matched age research groups: Research Group A:22 male patients 60 years old and above with knee osteoarthritis. Research Group B:22 female patients 60 years old and above with knee osteoarthritis. Results: Significant improvement in pain scores among all grades of knee OA, the best improvement achieved at 6 months follow up. Rate of improvement in pain Scores at 6 and 12 months follow up was almost equal between the 3 grades of OA with no statistically significant difference. Conclusions and Recommendations: Intra-articular injection of PRP in knee OA may be a valid alternative treatment for knee osteoarthritis. Intra-articular infiltration of autologous PRP under the conditions described in this study seems to be a safe, effective treatment for knee OA and does not require hospitalization or surgery.

Gender difference and therapeutic effectiveness of platelets rich plasma intra-articular injections among elderly with knee osteoarthritis