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Purpose: To evaluate the pain on injection of propofol via pretreatment with low dose of ketamine and low dose of Fentanyl in patients undergoing elective surgery under general anaesthesia. Methods: Total 60 patients were randomly allocated into two groups 6 groups. Group K (Ketamine Group): Received ketamine 0.15 mg/kg iv, 1 minute before injection of propofol and Group F (Fentanyl Group): Received Fentanyl 1.5mcg/kg iv, 1 minute before injection of propofol. All patients were monitored for the blood pressure (MAP), heart rate (HR), and oxygen saturation (SpO2). Additionally, the pain intensity was assessed using a 4-point verbal rating scale (VRS) by professional doctors. Results: The incidence of pain due to propofol injection in Group K 22 (62.85%) of the patients did not represent any pain and in Group F 24 (68.27%) of the patients does not show any pain during propofol injection. However, the difference between the two groups was statistically insignificant with p value of 0.782. Conclusion: From the findings of our study, it may be concluded that pre-treatment with low dose intravenous ketamine 0.15mg/kg and intravenous Fentanyl 1.5mcg/kg with a tourniquet just before propofol injection, significantly reduced the incidence and degree of propofol induced pain without significant adverse hemodynamic effects.

A Prospective Evaluative Study between Low Dose Ketamine and Fentanyl as Pre Medication for Alleviation of Propofol Injection Pain