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1 Department of Microbiology, GITAM Institute of Medical Sciences & Research, GITAM (Deemed to be University), Rushikonda, Visakhapatnam – 530045, Andhra Pradesh, India 2 Hemato-Pathologist, Mahatma Gandhi Cancer Hospital & Research Institute, 1/7, MVP Colony, Visakhapatnam – 530017.Andhra Pradesh, India 3 Surgical Oncologist, Mahatma Gandhi Cancer Hospital & Research Institute, 1/7, MVP Colony, Visakhapatnam – 530017.Andhra Pradesh, India 4 Department of Biochemistry, GITAM Institute of Medical Sciences & Research, GITAM (Deemed to be University), Rushikonda, Visakhapatnam – 530045, Andhra Pradesh, India *Corresponding Author Dr Viswa Kalyan Kolli Associate Professor, Department of Biochemistry, GITAM Institute of Medical Sciences & Research, GITAM (Deemed to be University), Rushikonda, Visakhapatnam – 530045. Andhra Pradesh. India Abstract Introduction: Febrile neutropenia is commonly seen in patients undergoing chemotherapy that makes them susceptible to infections. Procalcitonin (PCT) is routinely used as a marker of systemic infections. Recently, Red Cell Distribution Width (RDW) and Platelet Distribution Width (PDW) were also indicated for the presence of infections. The aim of the study was to find the clinical utility of RDW and PDW along with PCT as biomarker for early institution of antibiotic therapy. Materials & Methods: 150 patients with haematological malignancies who had chemotherapy-induced neutropenia were included in the study and were tested for PCT, RDW and PDW. Results: 42 patients who tested negative for PCT were considered as Control and the 108 patients who tested positive for PCT were considered as Test. RDW and PDW values were significantly increased in the test group (RDW: 51.9+10.29 and PDW: 12.2+3.56)as compared to the control group (RDW (SD): 43.49+7.98 and PDW: 10.76+1.78). Conclusion: RDW and PDW together with PCT can be used as biomarker for sepsis and early institution of antibacterial therapy.

Diagnostic Role of RDW & PDW as Early Markers of Sepsis in Chemotherapy Induced Febrile Neutropenia