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1 Assistant Professor, Department of Biochemistry, Govt. Medical College, Amritsar 2,4 Senior Resident, Department of Biochemistry, Govt. Medical College, Amritsar 3 Junior Resident, Department of Pediatrics, Govt. Medical College, Amritsar 5 Associate Professor, Department of Forensic Medicine, Govt. Medical College, Amritsar *Corresponding Author Dr Tejinder Singh Senior Resident, Department of Biochemistry, Govt. Medical College, Amritsar, India Abstract Objectives: The purpose of this study was to characterize the impact of hyponatremiaon clinical presentation and management in pediatric patients suffering from lower respiratory infection within 2 hours of admission in ICU and to investigate whether there is link between hyponatremia and the severity and outcome of LRIs. Methods: 100 pediatric patients of age group 2months to 5 years suffering from lower respiratory infections were recruited in the study. Clinical presentation and chest X ray were recorded. Serum sodium levels were assessed to diagnose Hyponatremia (s. sodium<135mEq/L). Appropriate fluid therapy was administered to each patient and impact of hyponatremia over isonatremia was evaluated in patients. Results: 75 were in the age group of 2months to 1year and 25 were in the age group of 1 to 5 years. 63 children had normal sodium levels (Isonatremia) and 33 children had hyponatremiaat the time of admission. Association of clinical symptoms and signs in isonatremic versus hyponatremic patients were not found significant statistically in both age groups (p >0.05). It was evident from these observation that abnormal x ray findings were more common in the hyponatremic cases (p=0.008) than the isonatremic cases (p<0.001). Association of requirement of i/v fluids in hyponatremic versus isonatremic patients was found to be significant statistically in both age groups (p value 0.000). Conclusion: Thus it is concluded that, presence of hyponatremia in LRI’s increases the morbidity of these patients as radiographic findings were more common. Therefore, fluid therapy is required more in Hyponatremic patients.

Impact of Hyponatremia on Clinical Presentation and Management in Pediatric Patients with lower Respiratory Infections