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Once severe ischemia has lasted for about 20 minutes, myocardial necrosis ensues, affecting the subendocardium first and then proceeding in a time dependent wave front to reach epicardium about 4 to 6 hours later. Restoration of blood flow before necrosis is transmural, arrests the progression of necrosis and salvages the still viable but ischemic myocardium that would otherwise proceed to necrosis. Aim: The objective is to assess the occurrence of complications of half dose of streptokinase versus full dose of streptokinase in three weeks follow-up following thrombolysis therapy. Material and Methods: Sixty elderly patients with acute myocardial infarction were enrolled in the study, presenting within 12 hours of onset of symptoms and having no contra-indication to thrombolytic therapy at GMC, Jammu for a period of one year w.e.f nov.2017 to oct.2018. Results: Out of the total 60 cases included in our study, 30 (50%) were assigned to the study group and 30 (50%) were included in the control group. Overall, 46 (76.7%) males and 14 (23.3%) females were included in the study. Conclusion: In the present study, we conclude that low dose streptokinase also achieved post-therapy outcome comparable to the standard dose, as assessed clinically and echocardiographically in a shortterm follow-up of three weeks.

Post-therapy outcome and echocardiographic analysis at three weeks of elderly patients with acute myocardial infarction following thrombolysis therapy