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1 Pharm. D Interns, P. Ramireddy Memorial College of Pharmacy, Kadapa 2 Assistant Professor, Department of General Medicine, Rajiv Gandhi Institute of Medical Sciences, Kadapa 3 Associate Professor, Dept of Pharmacy Practice, P.Ramireddy Memorial College of Pharmacy, Kadapa *Corresponding Author K. Leela Prasad Babu Assistant Professor, Department of General Medicine, Rajiv Gandhi Institute of Medical Sciences, Kadapa Abstract Acute coronary syndrome (ACS) among Cardiovascular diseases (CVDs) is the major cause of mortality worldwide and are the leading cause of death in India also.ACS refers to any group of clinical symptoms compatible with acute myocardial ischemia and covers the spectrum of clinical conditions ranging from unstable angina to non-ST-segment elevation myocardial infarction (NSTEMI) to ST-segment elevation myocardial infarction (STEMI). Several surveys were conducted across the country over the past few years have shown a rising of major risk factors for CVD in all population. Depressive disorders are estimated as the second largest cause of loss in connection with social people and increased risk for death. Patients with postACS depression have significantly had more hospital visits and huge health care costs than similar patients without depression. The main aim of our study was to determine the clinical efficacy of antidepressants in post-acute coronary syndrome patients. A prospective observational study was done for about 6 months in general medicine and cardiology departments of Rajiv Gandhi Institute of medical sciences, a 750 bedded tertiary care teaching hospital. A total of 100 ACS patients were taken. Among 100 post ACS patients, 76 were found to have depressive episodes and were diagnosed with becks depression score by using 21 questionnaires and with DSV-V criteria. Most commonly used antidepressant was Sertraline. A Supportive measure such as preoperative counseling should be provided to prevent post-ACS depression was undertaken prior to therapy was significant to reduce the depressive condition.

Clinical Profile of Depression and Treatment with Antidepressants in Post Acute Coronary Syndrome Patients