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Locally advanced carcinoma of gall bladder is a disease with a dismal prognosis. Chemotherapy is the main stay of treatment, but there is no standard chemotherapy options for patients with GB carcinoma Aim: To compare the overall survival, time to disease progression and toxicity between the two chemotherapeutic regimens Materials and Methods: Single institution retrospective study in 2018 of patients treated with capecitabine and gemcitabine based chemotherapy-gemcitabine either with cisplatin or carboplatin. A total of 230 patients were identified, of whom 67 patients were treated with chemotherapy,34 received capecitabine and 33 patients received gemcitabine either with cisplatin or carboplatin Results: We observed the overall survival and time to disease progression were similar in outcomes in both regimens. No major acute toxicities seen in both arms Conclusion: Gemcitabine based chemotherapy provides similar outcomes to capecitabine, but capecitabine also offers the advantage of oral dosing thus facilitating drug delivery and patient compliance

journal of medical science and clinical research

Retrospective Comparative Study between Capecitabine and Gemcitabine Based Chemotherapy in the Treatment of Locally Advanced Unresectable Carcinoma of Gall Bladder