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1 Senior Resident, Department of Anaesthesiology, Government Medical College, Datia 2 Demonstrator, Department of Biochemistry, Government Medical College, Datia 3 Associate Professor, Department of Anaesthesiology, Government Medical College, Datia *Corresponding Author Dr Dinesh Maraiya Demonstrator, Department of Biochemistry, Government Medical College, Datia, India Abstract Introduction: Spinal anaesthesia with local anaesthetic agents and adjuvant is extensively used for lower abdominal surgery. Neuraxial opioids have effective postoperative analgesia without sensory or motor blockade. But in spite of ease of administration and patient comfort, worrisome adverse effects like potentially catastrophic respiratory depression, urinary retention, vomiting, pruritus, etc. Material and Method: The present study entitled was carried out in the Department of Anaesthesiology M.G.M Medical College & M. Y. Hospital, Indore after approval of a hospital ethics committee this study was carried out on 90 patients admitted for lower limb surgery, under intrathecal block. The study was conducted on 90 patients aged between 18 to 60 years of ASA class I and II posted for lower limb surgeries. The patients were randomly divided into three groups of 30 each according to drug used for intrathecal block. Result: Ninety patients of physical status I and II as per American Society of Anaesthesiologists, of either sex, in age groups 18 to 60 years undergoing elective lower limb surgeries under SAB were subject of the study. Patients were randomly divided into three groups of thirty patients each to receive different doses of Midazolam (0, 1 and 2 mg with 15 mg bupivacaine) by adopting block randomization method. Statistical comparison that in control group patients there is no significant difference in complications rate and dose strength of Midazolam administered. Bradycardia and hypotension responded to treatment. Twenty tree patients from all groups had bradycardia that is pulse rate less than 60 bpm. All patients responded to intravenous atropine injection 0. 6 mg. Discussion: Incidences of various complications – nausea, vomiting, bradycardia, hypotension and shivering, noticed in patients receiving Midazolam were not significant when compared with control group patients. Statically data analysis were revealed that there were no significant changes present.

journal of medical science and clinical research

Complication of regional anaesthesia in addition of midazolam with hyperbaric bupivacaine 0.5% in intrathecal block – A Comparative Study done in tertiary care centre