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Background: Work on the comparison of liver enzymes between newly diagnosed type-2 diabetes mellitus (T2DM) and established T2DM can be an indicator of insulin resistance. Objective: To compare the serum levels of alanine amino transferase (ALT), aspartate amino transferase (AST), and γ-glutamyle transferase (GGT) in patients with newly diagnosed and established T2DM in rural Jaipur (India). Material and Methods: A cross-sectional study comprises with 240 subjects, divided into three groups of 80 each including control. (a): 80-newly diagnosed type-2 DM, (b): 80-established T2DM and (c): 80healthy age and sex matched controls. Fully automated analyser (HUMAN) was used for biochemical analysis of FPG, ALT, AST, GGT. Chi square (χ 2 ) test and Z-test were used for statistical analysis. P<0.05 was considered as significant. Results: Highly significant association was found between newly diagnosed T2DM with raised ALT/ raised GGT, and no significant association was found between newly diagnosed T2DM and raised AST with compare to established T2DM. Conclusion: Rise of ALT and GGT in newly diagnosed T2DM represents insulin resistance due to accumulation of fat in hepatocytes and indicates more oxidative stress due to lipid per-oxidation, βoxidation. Rise in AST is nonspecific to liver involvement in T2DM and might be due to other manifestations.

journal of medical science and clinical research

Comparison of Liver Enzymes (ALT, AST &amp; GGT) in Patients with Newly Diagnosed and Established Type-2 Diabetes Mellitus in Rural Population of Northern India