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Blood transfusions are inevitable element of modern medicine. Simultaneously, it is not a risk free procedure. It is associated with transfusion transmissible infections (TTIs) and transfusion reactions. Approximately, 1% of transfusions are associated with adverse events. [1] TTIs include human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV), Syphilis and Malaria. Outcome of TTIs ranges from subclinical to life-threatening manifestations of diseases. Various testings are helpful to reduce TTIs, but not up to 100%. There is always chance of false-negative due to detection limitation of kits used and “window period” of diseases. Minimizing its use and taking donation from low risk population for TTIs are some of the modalities used for reduction for adverse events associated with blood transfusions.

Transfusion transmissible infections in blood donors in central India at Indore: A 7 year study