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1 Postgraduate Resident, M.G.M Medical College Indore 2 Assistant Professor, RKDF Medical College Bhopal *Corresponding Author Swati Agarwal Assistant Professor, Department of Biochemistry, RKDF Medical College Bhopal, MP, India Mob: 09424438779, Email: drswati.agl@gmail.com Abstract Aims & Objective: To compare various serum lipid parameteres in young healthy off-spring of diabetics (single or both parents) with offspring of non-diabetic parents. Material and Methods: A cross sectional study with 120 subjects included ,60 normal healthy off-springs of diabetic parents (single parent diabetic 38 & both parent Diabetic 22) and 60 normal healthy off-springs of non-diabetic parents between age group of 18 to 30 years. All inclusion and exclusion criteria were applied after which subjects were enrolled and also informed written consent were taken. Serum lipid cholesterol level assay was done by Modified Roeschlaus’s method (Dynamic extended stability CHODPOD method) by Fully Automatic Analyzer. Results: The mean value of Serum HDL was lower in off-springs of both diabetic parents than offspring of non-diabetic parent and the difference was statistical significant (p=0.005**). We found Statistical significant difference in mean value of Serum HDL between offspring of single diabetic parent and offspring of non-diabetic parent (p= 0.042*) and mean value of Serum HDL was lower in offspring of both diabetic parents than offspring of single diabetic parent but the difference was not statistical significant (p=0.522). Conclusion: Lipid profiles of off-springs were related to diabetic parent’s history. When both parents are diabetic their offspring should always be kept in follow-up as they have high chances of developing hyperglycemia in future.

A Cross-sectional Study of Profile Serum Lipid levels in off-springs of Diabetic patients in a Tertiary Care Hospital in Central India