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The circadian periodicity of plasma lipid peroxide levels and activities of superoxide dismutase (SOD), catalase (CAT) and Total antioxidant status (TAS) were studied in 50 clinically, alcoholic hepatitis proven fresh cases (age: 18-70 years) and 50 age matched healthy volunteers with diurnal activity from 06:00 to about 22:00 and nocturnal rest. A marked circadian variation in plasma lipid peroxide level was recorded in healthy subjects and alcoholic patients with significant amplitude and acrophase around 16:21 and 17:12 respectively. The acrophase tended to be delayed in alcoholic patients. Furthermore, a statistically significant circadian rhythm was found in SOD, CAT, TAS, and MDA activities in normal volunteers and alcoholic hepatitis patients (AH). SOD and CAT enzyme activity was noted to be maximum at 06:00 and minimum at 00:00 in alcoholic hepatitis patients. The circadian acrophase for GPx activity was recorded at 16:15 in normals and around 22:45 in patients. Moreover, the activity was found to be decreased at all sampling hours during 24-hours sleep-awake period in patients in comparison to healthy counterparts. The MESOR and circadian amplitude also decreased markedly. The decreased activity of measured antioxidant enzymes in pulmonary tuberculosis patients could probably be associated with oxidative stress and/or decreased anti-oxidant defensive mechanism in such patients.

Chronobiological Variation of Oxidative Stress Markers in Alcoholic Hepatitis Patients