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1 Assistant Professor, 2 Senior Resident Department of Medicine, F.H. Medical College, Ethmadpur Agra, India Corresponding Author Rameshwar Dayal Assistant Professor, Department of Medicine, F.H. Medical College, Ethmadpur Agra, India Abstract Severe malaria caused by P. vivax infection. Monoinfection by P. vivax can cause severe malaria as seen in P. falciparum. Aims and Objectives: To study clinical profile of plasmodium vivax patients admitted in tertiary care center inn Agra and there outcome. Method and Material: This prospective observational study was carried out at F. H. Medical college and Hospital Ethmadpur Agra, included P.vivax positive cases confirmed by both thick and thin blood filmed stained with leishman’s stain for malarial parasite and M.P. Elisa. Detailed history, clinical examination, liver, renal and hematological parameter was done in all patients. Results: We studied total 180 patients with plasmodium vivax infection out of which 86 males and 94 females. Most patients with age group 21-30 years (63.3%). Severe malaria was present in 56 cases. Thrombocytopenia (52%) was most common complication followed by hepatic (25%), renal(18.5), cerebral(2.7) involvement. Conclusions: Severe Plasmodium vivax malaria now very common with increasing renal, liver dysfunction and with altered hematological profile. Keyword: Plasmodium vivax; liver dysfunction; renal dysfunction; hematological profile.

To study the clinical profile of severe plasmodium vivax malaria experience from tertiary care Centre in Agra