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1 Department of Skin and VD, IMS and SUM hospital, Siksha “O” Anusandhan Deemed to be University, K8, Kalinganagar, Bhubaneswar-751003, Odisha, India 2 Medical Research Laboratory, IMS and SUM hospital, Siksha “O” Anusandhan Deemed to be University, K8, Kalinganagar, Bhubaneswar-751003, Odisha, India Corresponding Author* Dr Mahesh Chandra Sahu Assistant Professor, Medical Research Laboratory, IMS and SUM Hospital, Bhubaneswar Email: mchsahu@gmail.com Abstracts Purpose: The bacterial manifestation in Skin ulcer is a common type of disease affecting patients' health and quality of life. Due to increases in antibiotic resistance, the difficulty of its management. Methods: A prospective study was carried out on skin ulcers by collecting the results of bacterial culture sampled of 110 cases from January 2016 to December 2017 at our hospital. We analyzed the constituent ratios of ulcer surface bacteria, the change in the main infectious bacteria and the results of drug sensitivity testing for common bacteria. In addition, the characteristics of bacterial infection of skin ulcers were summarized. Result: Out of 110 samples, 90 isolated bacteria were cultured. 61 samples were Gram-negative bacteria, mainly comprising Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter cloacae and Escherichia coli. In addition, 23 isolates were Gram-positive bacteria, mainly comprising Staphylococcus aureus and Enterococcus faecalis. The probability of a negative bacterial culture in 2017 was significantly lower than that in 2016 (16.7% vs. 40.0%, p < 0.01). Moreover, the probability of P. aeruginosa infection in 2017 was significantly higher than that in 2016 (31.7% vs. 14.0%, p < 0.01). P. aeruginosa was resistant to seven commonly used antibiotics. Both K. pneumoniae and E. coli had higher resistance to ampicillin. E. cloacae were not sensitive to piperacillin/tazobactam. Acinetobacter baumannii was resistant to all the tested drugs. S. aureus, E. faecalis and Staphylococcus epidermidis had high resistance to clindamycin. There was other drug resistance to reflect the higher rate of skin bacterial resistance. Conclusion: Skin bacterial resistance rate is high. Gram-negative bacteria gradually account for the majority, and P. aeruginosa becomes the most important skin infection pathogen. These characteristics of bacterial infections of skin ulcers provide a significant reference for guiding the selection of antibiotics, better controlling infections of skin ulcers and accelerating the healing of skin ulcers.

Surveillance of drug sensitivity of bacteria in skin ulcer infections