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Objective: To study the efficacy of single dose of preoperative dexamethasone in the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Materials and Methods: 110 patients were randomized in two equal groups. Each of the groups received either 2ml (8mg) intravenous dexamethasone (Group A) or 2ml intravenous normal saline as placebo (Group B). Results: 6 patients (14.5%) in group A and 19 patients (34.5%) in group B had postoperative nausea and vomiting in first 6 hours whereas 2 patients (3.6%) in group A and 5 patients (9.0%) in group B had postoperative nausea and vomiting in 6-24 hours. Conclusion: Preoperative dexamethasone improves the surgical outcome by reducing disabling symptoms of nausea and vomiting without apparent side-effects. So we suggest that single dose of preoperative dexamethasone should be used as a routine in patients undergoing elective laparoscopic cholecystectomy.

journal of medical science and clinical research

The effect of single dose of preoperative dexamethasone on postoperative nausea and vomiting after laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled study