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1,2 Tutor, Department of Pharmacology, Sri Krishna Medical College, Muzaffarpur 3 Professor & HOD, Department of Pharmacology, Sri Krishna Medical College, Muzaffarpur 4,5 Associate Professor, Department of Pharmacology, Sri Krishna Medical College, Muzaffarpur Corresponding Author Dr Deepak Kumar Associate Professor, Department of Pharmacology, Sri Krishna Medical College, Muzaffarpur Abstract Objective: A Prospective study to evaluate the effect of Prophylactic administration of natural micronized progesterone vaginally, on the occurrence of spontaneous Preterm birth in high risk woman. Materials and Methods: A total of 60 Pregnant woman attending the GOPD and all women fulfilling inclusion criteria were examined thoroughly. Half of the women under the study received 200mg natural micronized progesterone per vaginally twice daily. The treatment continued up to 36 weeks of gestation if not delivered earlier. Another half did not receive any progesterone supplement and this group served as control. Finally incidence of preterm labour among both the groups were compared. Results: Incidence of preterm delivery was significantly low in those receiving vaginal natural micronized progesterone than those who did not receive. Conclusion: Vaginally administered natural micronized progesterone was found beneficial for mothers with past history of spontaneous preterm labour.

journal of medical science and clinical research

Prevention of Preterm Labour in High Risk Woman by Vaginally Administered Natural Micronized Progesterone in Tertiary Care Hospital at Muzaffarpur, Bihar