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Background: India is one of the largest consumers of tobacco worldwide. Addiction of tobacco smoking is related with many health hazards. Nicotine of tobacco can be attributed to changes in lipid profile and its atherogenic complications. Aims and Objectives: To study and compare lipid levels with severity and duration of smoking in healthy subjects. Materials and Methods: Fifty current regular smoker subjects were studied in JA Group of Hospitals and GR Medical College, Gwalior from June 2014 to October 2015.Depending on severity of smoking subjects were classified as mild smokers (regularly between 1-10 cigarettes or bidis/day), moderate smokers (regularly between 11-20 cigarettes or bidis/day and heavy smokers (regularly > 20 cigarettes or bidis/day. Depending on duration of smoking subjects were classified as those between 1-10 years of duration, between 11-20 years of duration and >20 years of smoking duration. All the subjects underwent estimation of total cholesterol (TC), triglycerides (TG), low density lipoproteins (LDL), high density lipoproteins (HDL) and HDL / TC ratio. Results: Mean TC in smoker and non smoker was 202.2± 26.7 vs 162.2± 22.2 (p < 0.001), mean TG was 195.2±46.3 vs. 145.1±24.1 (p<0.001), mean LDL was128.0 ±28.3 vs. 92.5±20.9 (p<0.001) and mean HDL was34.2±5 vs. 42.2±4.6 (p<0.001) mg/dl respectively. TC (235.7±0.56 vs. 209.6±22.6 vs. 178.9±20.0 respectively), TG (198.6±4.4 vs. 197.1±48.8 vs. 191.3±34.9 respectively) and LDL (170.7±7.7 vs. 136.7±24.3 vs. 107.3±22.9 respectively) were higher in heavy smokers compared to moderate and mild smokers, whereas HDL (32.3±.21 vs. 33.4±4.4 vs. 39.9±6.2 respectively) was lower in heavy smokers compared to moderate and mild smokers. Conclusion: A direct relationship exists between severity and duration of smoking with an increase in Total Cholesterol, Triglycerides and Low Density Lipoproteins.

To study the Effect of Duration of Smoking on Lipid Parameters in Otherwise Healthy Subjects