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Department of Anesthesiology and Pain Medicine, Govt. Medical College Kota Corresponding Author Dr Chiranji Lal Khedia Email: khedia7685@gmail.com Abstract Introduction: PONV is a major complication after anaesthesia, present in 20-30% range 1 . We compared efficacy and tolerance of ondansetron and palonosetron for PONV prohylaxis in patients posted for elective laproscopic cholecystectomy. Method: 60 patients of age 20-60 years ,ASA I and II, scheduled for elective laproscopic cholecystectomy were randomized double blindly to receive either 8 mgbolus IV ondansetron and 16 mg was added to the PCA mixture (O group),or 0.075mg palonosetron only bolus dose (P group). Pregnancy, known hypersensitivity to both drugs, migraine, motion sickness were excluded. Chi squre test and Fisher exact test were used for statistic evaluation. Microsoft excel and epi info version 3.4.3 were used. P value <.05 considered significant. PONV (0 no nausea, 1 nausea,2 retching,3 vomiting), rescue antiemetics and side effects were assessed in 24 hr postoperative period. Result: Both groups were comparable in demographic parameters (age, sex, weight). Overall incidence of PONV did not differ significantly (p=.57) but patients, who needed rescue antiemetics were significantly less in group P than group O (P=<.05). Additionally side effects were also less in group P. Conclusion: In patients undergoing elective laproscopic chlecystectomy, use of palonosetron significantly reduced need of rescue antiemetics. Incidence of PONV and side effects were also less with P group.

journal of medical science and clinical research

Comparison of intravenous ondansetron and palonosetron in prevention of postoperative nausea and vomiting in patients posted for elective laproscopic cholecystectomy