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Background & Objectives: There is growing evidence that periodontitis may affect general health. Periodontal disease is now recognized as the sixth complication of diabetes. It has been suggested that an alteration in glucose metabolism occurs as a result of antibacterial periodontal therapy. The present study is aimed to evaluate the clinical and metabolic changes in type-2 diabetic patients with chronic periodontitis after non-surgical periodontal therapy with or without the systemic administration of azithromycin. Method: In our study24 patients with type-2 diabetes having chronic periodontitis were included. Group I included 12 patients who underwent scaling and root planing (SRP) only and group II 12 patients who underwent SRP with concomitant systemic administration of azithromycin 500mg once daily for 3 days. At baseline, plaque index (PI), gingival index (GI), probing depths (PD) were recorded and glycated haemoglobin (HbA1c) levels were evaluated. Patients were followed for 30-90 days. Results: The mean decreasein glycosylated hemoglobin (HbA1c) was 0.18± 0.5 after nonsurgical periodontal treatment in group I on comparing the baseline (8.98± 0.99) and final values (8.8± 1.10), and in group II was 1.18± 0.47on comparing the baseline (9.01± 1.18) and final values (3.36± 1.87) proved statistically significant (P≤ 0.05). Conclusion: A decrease in HbA1c was observed in group II (SRP+Azithromycin 500mg once daily3 days) thus indicating improved blood glucose control in Type 2 diabetics with periodontal disease compared to group I (SRP only).

journal of medical science and clinical research

Clinical and Metabolic changes after the Non- surgical Periodontal Therapy in patients with Type-2 Diabetes Mellitus with Chronic periodontitis with or without the Systemic administration of Azithromycin - A Randomized Controlled Clinical Trial