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Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder in which there is insulin resistance and it is experienced by insulin sensitive tissues like skeletal muscle, adipose tissue, liver, and small part of cardiac tissue. The present study was conducted for 12 weeks in the male Wistar rats to investigate the effect of High Sugar Diet (HSD) and melatonin in relation to plasma glucose, serum levels of interleukin-6 (IL-6), and levels of Magnesium (Mg) in serum, liver, pancreas and kidney tissues. The study also investigate that melatonin administration increases the Mg levels in serum and above mentioned tissues. We observed increased levels of plasma glucose, serum IL-6, and lower levels of Mg in serum and kidney tissues in HSD rats when compared with control rats. After administration of melatonin to HSD rats, significant decrease was observed in the values of plasma glucose and serum IL-6. On the contrary, we observed significant increase in the levels of Mg in the serum and kidney tissues when melatonin was administered to HSD rats. Thus, we conclude that the response to melatonin administration for glucose, Mg, and IL-6 parameters is related to the degree of insulin resistance and the duration of the study. The response to melatonin is also related to physical stress, to the types of diet consumed.

Effect of Melatonin in High Sugar Diet fed Male Wistar rats on the levels of Plasma Glucose, Magnesium, and interleukin-6