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Objective: To find out the role of dyslipedemia as a contributing factor in heart failure cases and study comparatively with the Framingham study (Meta analysis). Methods: This was a crosssectional study conducted in a tertiary care hospital. The study was approved by the ethics committee of the institute and consent was taken from each participant before enrolling in the study. A total of 100 cases with signs and symptoms of heart failure (Acute/Acute on Chronic and Chronic heart failure) were included in the study. Background: The relationship of lipid concentrations to heart failure has been evaluated in a study derived from Framigham Heart study participants. Introduction: Heart Failure (HF) is a syndrome associated with high morbidity and mortality and enormous economic burden, rendering prevention a priority. 1 Elucidating modifiable risk factors for HF will aid the identification and promulgation of prevention strategies. Dyslipidemia is a well-established risk factor for coronary heart disease (CHD) 2 and results from clinical trials of lipid-modifying therapy demonstrate that treatment with statins also decreases the incidence of HF. 3 This finding suggests that dyslipidemia is a risk factor for HF, although the association may be mediated by the occurrence of myocardial infarction (MI). The Framingham Heart Study detected a direct association between the ratio of total cholesterol to HDL-C and HF risk, 5 suggesting that either elevated total cholesterol, or a lowered HDL-C may influence HF risk. Although previous studies assessed the associations between individual lipid measures and HF, 4,5 the role of lipids in the incidence of HF in people without pre-existing CHD has not been systematically investigated in a community-based setting in a prospective fashion, with appropriate adjustment for clinical factors (including interim occurrence of MI) that influence HF risk. Elevated low density lipoprotein cholesterol (LDL-C) and decreased high density lipoprotein cholesterol (HDL-C) have been shown to be associated with reduced systolic and diastolic LV function. 6,7 . Also a previous investigation from the Framingham Heart Study detected a direct association between the ratio of total cholesterol to HDL-C and HF risk, 5 suggesting that either elevated total cholesterol, or a lowered HDL-C may influence HF risk. ‘ In our study 100 participants (49% women) patients with unadjusted HF incidence in the low (<160mg/dl) vs. high (≥190mg/dl) non-HDL-C groups was 7.9% and 13.8%, respectively, whereas incidence in the high (≥55 [men], ≥65 [women] mg/dl) vs. low (< 40 [men], <50 [women] mg/dl) HDL-C groups was 6.1% and 12.8%, respectively. In multivariable models, baseline non-HDL-C and HDL-C, carried HF hazards (confidence intervalCI) of 1.19 (1.11–1.27) and 0.82 (0.75–0.90) respectively per standard deviation (SD) increment .Participants with high baseline non-HDL-C and those with low HDL-C experienced a 29% and 40% higher HF risk respectively, compared to those in the desirable categories; the PARs for high non-HDL-C and low HDL-C were 7.5% and 15% respectively. Dr Prodeep Kumar et all. / The possible attribution of abnormal lipid concentrations in Heart Failure: A comparative

The possible attribution of abnormal lipid concentrations in Heart Failure: A comparative study.