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Objectives: The purpose of this study is to evaluate the mutagenicity, antimutagenic and radical scavenging activities of Mineral Trioxide Aggregate (MTA), a material widely used in various dental procedures. Although there have been several studies that discuss MTA’s antifungal and antibacterial properties, we believe this will be the first report to evaluate the antimutagenic and radical scavenging properties. Methods: Free radical scavenging activity was determined according to the elimination of 1,1-diphenyl-2-picryl hydrazyl (DPPH) radicals. Antimutagenesis studies were performed with the Salmonella/microsome mutagenesis test. These assays were done on Salmonella typhimurium TA98 and TA100. Results: MTA has low radical scavenging activity with a total of 8.95% and revealed strong antimutagenic effects at all of the tested concentrations. Significance: Considering the results obtained in this study, MTA showed great antimutagenic attributes which may be considered a positive feature for a material widely used in dentistry.

Determination of the Free Radical Scavenging and Antimutagenic Activity of Mineral Trioxide Aggregate, Root Canal Treatment Material Used In Dentistry