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Mice can regenerate tissue in the third phalanges of digit tip after amputation. The tissue regeneration process involved various cells, molecules, proteins, and genes that were thought to have a role in the process. Hedgehog (Hh) gene was thought to have a role in tissue regeneration, but research in adult tissue regeneration was limited. Hh gene had a role in mitosis and cell morphogenesis during the embryo growth. The expression of this gene continued in the adult cell population. We analyzed the Hh gene expression in tissue regeneration of the third phalange digit tip mice post-amputation until day 25. We used 30 males of mice (Mus musculus var Webster) as an animal model. We observed the histological analysis and Hh gene expression in each growth day. Spearman correlation test results in a strong and significant correlation between the growth length of digit tip mice and mRNA expression of the Hh gene (p <0.005; r= 0.874). Keywords: Hedgehog, tissue regeneration, digit tip, proliferation,

kne life sciences

The Correlation Between mRNA Hedgehog (Hh) Gene Expression with the Growth of Length of Tissue Regeneration Digit Tip Mice (Mus musculus) Post Amputation