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Aplasia cutis congenital (ACC) in lower legs is a rare disease with the absence of the skin, which commonly localized, widespread or scarred at birth. The exact pathophysiology remains unclear, and varicella infection may have essential roles in the aetiologies. Wound healing can be accelerated by using Human Dermal PapillaeConditioned Medium (HDPCM) which has multi-lineage potential differentiation and releases many growth factors. This paper reports the possibility of using human dermal papillae conditioned media to speed up the wound healing process. A 4 days old baby boy presented with ulcers on his both knees since birth and had no history of birth trauma. The mother had varicella infection during the 2

The Use of Human Dermal Papillae Conditioned Medium (HDPCM) on Aplasia Cutis Congenita in Lower Extremity due to Intrauterine Varicella Infection