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Softcoral has a potency as the new source of bioactive compound. This research aims to study antibacterial activity from several softcorals. Samples were identified as Sinularia, Sarcophyton and Lobophytum taken from Tulamben, Bali. Samples were extracted by maceration technique with methanol (70, 80, and 96%) and dried by rotary evaporation. Antibacterial activity of the extracts was tested by agar diffusion method to pathogenic bacteria such as Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus,and Streptococcus pyogenes. Antibacterial activity results were: Sarcophytonshowed highest activity, followed by Lobophytum and Sinularia. The most inhibited bacterium was P. aeruginosa. Methanol 80 and 90% showed similar results, while 70% resulted below them. Minimum inhibitory concentration (MIC) of Sarcophyton(96% methanol extract) to P. aeruginosa was 4% v/v.Keywords: Softcoral, antibacterial, Sinularia, Sarcophyton,Lobophytum

COMPARATIVE STUDY OF ANTIBACTERIAL ACTIVITY OF METHANOL EXTRACT OF Sinularia, Sarcophyton, AND Lobophytum FROM TULAMBEN, BALI