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The hemostatic properties of platelets to a large degree determine the activity of metabolic processes that have great biological significance especially in early ontogeny. This study was conducted on 43 calves of the Holstein breed during the phase of milk-vegetable diet. It was found during the observation period that the indicators were stable in the calves between 31 and 60 days of life, and the platelet aggregation weakened. In the blood of the calves of the Holstein breed there was a slight increase in the number of discocytes. The total number of active thrombocytes in calves observed after stability between 31-60 days of life decreased during the follow-up observation. The levels of circulating platelet aggregates of small and large sizes decreased between 60 and 90 days by 66.7% and 2.5 times, respectively. This contributed to a weakening of the calves’ platelet synthesis of thromboxane, a decrease in the content of adenosinfosfatom, and to inhibition of their secretion. During the observation period, the number of actin and myosin in the platelets of the animals also decreased, which reduced the overall platelet activity. In the second part of the phase of lacto-vegetarian nutrition, the synthesis of actin and myosin in the exposed aggregate platelets weakened in the calves. The stability of the hemostatic platelet counts of the Holstein calves at the age of 31-60 days was typical, which changed their physiologically acceptable weakening by the end of observation. Keywords: calves, dairy plant phase, Holstein breed, platelets, aggregation, secretion

Physiological Characteristics of Platelet Activity in Calves of the Dairy and Plant Nutrition of the Holstein Breed