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Background: Knee disease is prevalent in the post middle-aged and associated with lower quality of life. Knee disease (i.e., anterior cruciate ligament, ACL) related injury preventive program should be supported. We examined the significant effect of different age, gender, and exercise modalities on measureable nine dependent markers in National Health Insurance Sharing Service database (NHISS DB) registered ACL patients using big data analysis. Methods: The 1755 ACL patients from 514,866 in NHISS DB have been randomly selected by retrospective cohort study using big data from 2002 to 2013. Six independent and 9 dependent variables were used for analyzing patients with ACL injuries by T-test and Two-way analysis of variance (ANOVA). Results: Mean (SD) (men vs. women) of BMI, high blood pressure (BP), serum glutamic oxaloacetic transaminase (SGOT), and total cholesterol were 24.38±2.72 vs. 24.86±3.12 (P<0.01, 95% C.I., −0.763 ∼ −0.194), 126.64±14.70 vs. 125.02±16.62 (P<0.05, 95% C.I., 0.104 ∼ 3.151), 27.63±12.18 vs. 24.27±8.48 (P<0.01, 95% C.I., 2.393 ∼ 4.331), 197.77±37.60 vs. 205.72±36.72 (P<0.01, 95% C.I., −11.533 ∼ −4.378), respectively. Age and the frequency of 20 min severe exercise per week (Move20_Freq) intensive exercise had a significant association with BMI (P<0.05). Gender and Move20_Freq had a significant association with BP (P<0.05). Conclusion: Age-dependent Move20_Freq is associated with BMI in ACL patients. Women with ACL have higher BMI and cholesterol levels than men. These gender-specific differences can be relieved by exercise.

iranian journal of public health

The Effect of Significant Exercise Modalities, Gender and Age on 9 Markers (Indicators) in NHISS Registered ACL Patients for Designing Exercise Intervention Program