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Cardiovascular disease (CVD) is a group of diseases involving heart and blood vessels. In developed countries, coronary heart disease (CHD) is the main cause of death and disability (1, 2). Although the death rate has gradually decreased in western countries in the last few decades, one third of the population over 35 still died of this disease (3, 4). Of the 58 million deaths worldwide in 2005, 17 million died of CVD, of which 7.6 million died of CHD (5, 6). Interventional therapy is an important method to reduce the area of myocardial infarction clinically. In non-acute cases, the potential benefits of percutaneous coronary intervention (PCI) for stable CHD patients have been debated for more than ten years. One of the safety issues is in-stent restenosis (ISR), which has an incidence of 26.4%, seriously affecting the treatment effect and quality of life of paAbstract Background: To explore the changes of miR-130a and endothelin -1 (ET-1) and their predictive value for instent restenosis (ISR) after percutaneous coronary intervention (PCI). Methods: Overall, 253 patients with coronary heart disease (CHD) treated with PCI in Lianshui County People's Hospital, Huaian, China from April 2013 to May 2016 were selected. The changes of miR-130a and ET-1 levels before and after PCI were compared. The predictive value of miR-130a and ET-1 for ISR was analyzed by receiver operating characteristic (ROC) curves, and the correlation between ISR and miR-130a, ET-1 was analyzed by Kaplan-Meier (K-M) curve. The risk factors of ISR in CHD patients were evaluated by logistics regression analysis. Results: The postoperative levels of miR-130a and ET-1 were significantly increased (P<0.05). The levels of miR-130a and ET-1 in peripheral blood of patients with ISR were higher than those in patients without ISR (P<0.05). The ROC curves showed that the area under curve (AUC), sensitivity, specificity and critical value of miR-130a in predicting ISR were respectively 0.912, 92.02%, 73.47%, 1.457 pmol/L, and those of ET-1 were 0.814, 87.63%, 63.27%, 2.245 pmol/L, respectively. The K-M curve showed that the incidence of ISR in patients with high expression of miR-130a or ET-1 was significantly higher than that in patients with low expression (P<0.05). miR-130a and ET-1 were independent risk factors for ISR (P<0.05). Conclusion: MiR-130a and ET-1 have high predictive value for ISR after PCI and are independent risk factors for CHD patients, which are worthy of clinical application.

Changes of miR-130a and ET-1 and Their Predictive Value for In-Stent Restenosis after Percutaneous Coronary Intervention