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ype 2 diabetes mellitus (T2DM) often is related to dysfunction of β-cells of pancreas and lower level of insulin secretion. Reduced level of insulin secretion is often associated with increased insulin resistance, increased release of glucosedependent glucagon from liver deposits, and a rapid increase in glucose uptake from nutrients (1). Based on the presented laboratory evidence, destruction of pancreatic β-cells is a hallmark of T2DM, which is related to a reduction in the synthesis and secretion of insulin. The mentioned destruction is also connected to dysfunction of incretin hormones. Clinical studies revealed that the rate of apoptosis in β-cells is faster than the T 1. Assistant Professor of Exercise Physiology, Qom University of Technology, Qom, Iran. 2. Assistant Professor, Department of Exercise Physiology, Faculty of Humanities Sciences, Islamic Azad University, Saveh Branch, Saveh, Iran.

iranian journal of diabetes and obesity

The Effect of High Intensity Intermittent Training (HIIT) on GLP-1R Expression in Pancreas Tissue and Serum Insulin of Male Wistar Rats with Type 2 Diabetes Mellitus