Brain Metastases From Hepatocellular Carcinoma: A Rare Case Report

Intrahepatic lesions of hepatocellular carcinoma (HCC) have been controlled by significant advances in treatment, including chemotherapy, surgery, and ablative therapy. Consequently, the number of patients with extrahepatic metastatic lesions has increased, including lung, regional lymph nodes, peritoneum, and adrenal glands, but rarely to the brain. The prognosis of brain metastasis remains poor, with approximately <1 y of survival from the time of diagnosis. Although no guidelines for the brain metastasis of HCC have been developed to date due to the lack of the experiences and pieces of evidence, a molecularly targeted drug, sorafenib, have been used to treat extrahepatic lesions and shown the prolonged survival time. Therefore, the development of standard therapy for brain metastasis following the early diagnosis is essential by accumulating the information of clinical courses and pieces of evidence.