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Background: One of the important unsolved problems of hepatobiliary surgery is to stop the bleeding of the parenchymal organ. The most promising means of local hemostasis are spongy implants made of various materials, the study of which is one of the leading directions in modern surgery. Nevertheless, despite the relevance of the research, there is no uniform classification of the structural features of such hemostatics. Aims: to study the features of the surface of the application of hemostatic implants based on collagen and Carboxymethylcellulose Sodium. Materials and methods: the authors performed light microscopy of the samples, photographing and subsequent processing of the photographs obtained using the trial version of the graphic editor Adobe Photoshop CS6 (Adobe Systems, San Jose, United States of America) to obtain black and white images by enhancing the contrast (+400 ), which excluded the possibility of false color definition. The black and white pixels were counted using the Altami Studio 3.4 program (Altami LLC, St. Petersburg, Russian Federation). Then, the real pixel size was converted into percentages using the trial version of Statistica 10.0 (Dell Software Company, Round Rock, United States of America). After that, the ratio of low areas of the implant (black pixels) to high (white pixels) was determined.&#x0D; Results: According to the data obtained, a classification was developed for the heterogeneity of the surface of the relief of hemostatic implants, according to which all of them can be divided into three groups: with weak, moderate and strong severity of the heterogeneity of the surface relief. Conclusions: when correlating the obtained results and selected groups, it was found out that the hemostatic sponge Tachocomb (Takeda Pharmaceuticals LLC, Linz, Austria) has a slightly pronounced heterogeneity of the surface relief, and the hemostatic collagen sponge (OJSC Luga Belkozin, Luga, Russian Federation) and a Carboxymethylcellulose based hemostatic sponge (developed in cooperation with Linteks LLC, St. Petersburg, Russian Federation) - moderately pronounced surface heterogeneity.

Study of the Special Features of the Surface of Application Hemostatic Implants