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complications of this disease. Only in our clinic, the proportion of patients with destructive forms of erysipelas is about 18% of all patients of the Department of purulent surgery. The aim of the present investigation is to improve the results of treatment complications associated with erysipelas according to modern concepts about this problem. Methods We conducted a randomized controlled trial of 34 patients suffer from erysipelas, associated with purulent complications. All patients were categorized according to kind of treatment into two groups. The control group (17 patients) included patients treated with conventional therapy. In the main group (17 patients) in the conventional treatment of erysipelas was included immunomodulator Derinat. The efficacy of the treatment was monitored through clinical tests with calculation of indexes of intoxication (LII, YII), and special studies of the immune status. Results In patients treated with Derinat symptoms of intoxication were stopped in earlier periods (6 ± 0,58 (p<0,5) day, LII and YII was normalized on the 7th day) in comparison with the control group. After the traditional therapy, in patients was the suppression of T-lymphocytes and their subpopulations, ingestion rate was lower than in healthy persons. In the main group of patients after treatment with derinat we are reveal the stimulation of T - and B - immunity with increased ingestion rate. Discussion The inclusion of Derinat in the conventional therapy of patients with erysipelas allows to correct disorders in the immune status of these patients, which contributes to their rapid healing and reducing the risk of recurrence of the disease. Key words: erysipelas, destructive forms of erysipelas, complications of erysipelas, Derinat.

Derinat in Complex Treatment of Destructive Forms of Erysipelas