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Relevance. Treatment of venous ulcers so far is one of the most difficult tasks. In the context of impaired wound trophism in extremely slowed synthesis of tissue elements, so it seems appropriate to use the funds to stimulate regeneration. The purpose of the study. To evaluate the efficacy of different methods of regeneration stimulation in nonhealing wounds. Materials and methods. In order to investigate the clinical efficacy of a combination of concentrated platelets and suspension of native collagen unreconstructed for the topical treatment of venous ulcers, a comparative study with a control, parallel-group. Patients randomly assigned to the main group, which included patients who for the topical treatment of trophic ulcers used a combination of concentrated suspensions of platelets and native unreconstructed collagen and 3 control groups: the first - in the complex treatment of patients using advanced dressings, in the second - in the comprehensive topical therapy was used only collagen-containing preparations, in the third control group consisted of patients who have a comprehensive topical therapy using platelet rich plasma. The healing process was assessed by measurement of the ulcer, the skin around the wound, the bacteriological study of wound, cytological and pathological and histological studies of tissue injury, instrumental methods of research. Results. Use of a combination of concentrated suspensions of platelets and native collagen unreconstructed statistically significantly accelerates epithelialization of the wound surface efficiently stimulates granulation, substantially reduces adverse feeling in the wound. Key words: venous trophic ulcers, concentrated platelet suspension, collagen

vestnik èksperimentalʹnoj i kliničeskoj hirurgii

Evaluating the effectiveness of a combination of concentrated platelets and suspension of native collagen unreconstructed for the topical treatment of trophic ulcers of the small and medium-sized.