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The purpose of the study Analyzing the antioxidant and energy status of pancreatic tissue to study the mechanisms of influence of antioxidant and antihypoxic therapy in acute pancreatitis. Materials and methods Experimental work 46 animals, which were modeled edematous form of acute pancreatitis. In the control and study periods (1, 3 and 5 days) animals relaparotomy was performed in pancreatic tissue intraoperatively examined the redox potential and diffusion coefficient of oxygen, microcirculation was evaluated and morphological conditions. Performed a biopsy of pancreatic tissue for the purpose of studying the processes of lipid peroxidation. Animals of the first experimental series (n=12) in the postoperative period was carried out antioxidant therapy toxicol (10 mg/kg). Animals of the second experimental series (n=12) in the postoperative period was antihypoxic therapy remaxol (15 ml/kg). Results and their discussion Obtained during the execution of the research evidence shows that a certain "isolation" of the formation energy shortage and development of processes of lipid peroxidation. Recovery of tissue respiration in the pancreas does not reduce the intensity of the processes of lipid peroxidation. Conclusions The intensity of lipid peroxidation in pancreatic tissue is limited by other, additional mechanisms, eliminating the violation of the energy status of the tissue. Key words Acute pancreatitis, antioxidant, antihypoxic drug, tissue respiration, lipid peroxidation, mechanisms of influence

Oxidative status of pancreatic tissue on the background of the antioxidant and antihypoxic therapy